Oral pretreatment with liposomal glutathione attenuates reperfusion injury in rabbit isolated hearts.
Published: November, 2012 in the Journal of Cardiovascular Pharmacology
The study shows that pretreatment with liposomal glutathione will lessen damage to heart tissue due to a loss of blood flow. The study also shows that animals increased their brain GSH in a dose and time dependent fashion.
The hearts were subjected to 30 minutes of global ischemia followed by 60 minutes of reperfusion. Hearts from lipGSH-treated rabbits exhibited better recovery of left ventricular contractile function during reperfusion and had attenuated oxidative damage. Furthermore, hearts from lipGSH-treated animals had increased myocardial tissue levels of GSH demonstrating effective absorption of lipGSH.