Liposomal Glutathione

Studies Completed Involving ReadiSorb Liposomal Glutathione

The studies below were completed using liquid ReadiSorb Glutathione at independent laboratories, peer-reviewed and published on PubMed.

1. Anti-oxidant and anti-atherogenic properties of liposomal glutathione: studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice

Rosenblat M, Volkova N, Coleman R, Aviram M. December, 2007 in the Journal Atherosclerosis.

We thus conclude that liposomal glutathione possesses anti-oxidative and anti-atherogenic properties towards lipoproteins and macrophages, leading to attenuation of atherosclerosis development.

PMID: 17588583

2. Aminothiol receptors for decorporation of intravenously administered (60)Co in the rat

Tatiana G Levitskaia, James E Morris. January, 2010 in Health Physics Journal

Liposomal encapsulation was found to markedly enhance the oral bioavailability of GSH compared to non-formulated GSH. The oral administration of liposomal GSH reduced (60)Co levels in nearly all tissues by 12-43% compared to that observed for non-formulated GSH. Efficacy of oral Cys was only slightly reduced in comparison with intravenous Cys.

PMID: 19959951

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3. Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells

Gail D Zeevalk, Laura P Bernard, F T Guilford. October, 2010 in Neurochemical Research

No toxicity was observed with the liposomal preparation at 200-fold the EC(50) for repletion. These findings indicate that glutathione supplied in a liposomal formulation holds promise as a potential therapeutic for neuronal maintenance.

PMID: 20535554

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4. A clinical trial of glutathione supplementation in autism spectrum disorders

Janet K Kern, David A Geier. December, 2011 in Medical Science Monitor

The results suggest that oral ... glutathione supplementation may have some benefit in improving some of the transsulfuration metabolites. Future studies among subjects diagnosed with an ASD should further explore the pharmacokinetics of glutathione supplementation and evaluate the potential effects of glutathione supplementation upon clinical symptoms.

PMID: 22129897

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5. Oral pretreatment with liposomal glutathione attenuates reperfusion injury in rabbit isolated hearts

Lauver DA, Kaissarian NM, Lucchesi BR. December, 2011 in the Journal of Cardiovascular Pharmacology

Hearts from lipGSH-treated rabbits exhibited better recovery of left ventricular contractile function during reperfusion and had attenuated oxidative damage. Furthermore, hearts from lipGSH-treated animals had increased myocardial tissue levels of GSH demonstrating effective absorption of lipGSH.

PMID: 23188132

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6. Glutathione Supplementation Improves Macrophage Functions in HIV

Morris D, Guerra C, Khurasany M, Guilford F, Saviola B, Huang Y, et al. May, 2013 in the Journal Interferon and Cytokine Research

The results indicate that HIV infection leads to increased production of free radicals and decreased production of GCLC resulting in depletion of rGSH and this may lead, in part, to the loss of innate immune function observed in HIV patients.

PMID: 23409922

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7. Characterization of dendritic cell and regulatory T cell functions against Mycobacterium tuberculosis infection

Morris D, Gonzalez B, Khurasany M, Kassissa C, Luong J, Kasko S, et al. May, 2013 in BioMed Research International

The results indicate that GSH by its direct antimycobacterial activity inhibits the growth of intracellular M. tb inside DCs (dendritic cells).

PMID: 23762843

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8. An elucidation of neutrophil functions against Mycobacterium tuberculosis infection

Devin Morris, Minette Lagman, Vishwanath Venketaraman. November, 2013 in the journal Clinical & Developmental Immunology

They characterized the functions of neutrophils in response to Mycobacterium tuberculosis (M. tb) infection, with particular reference to glutathione (GSH).

PMID: 24312131

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9. Investigating the causes for decreased levels of glutathione in individuals with type II diabetes

Lagman M, Ly J, Saing T, Kaur Singh M, Vera Tudela E, Morris D, et al. March, 2015 in the Journal PLOS One.

Overall, the findings suggest that lower levels of GSH in individuals with T2DM lead to their increased susceptibility to M. tb infection.

PMID: 25790445

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10. Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals

Valdivia A, Ly J, Gonzalez L, Hussain P, Aing T, Islamoglu H, et al. July, 2015 in the Journal of Interferon & Cytokine Research

Furthermore, we demonstrate that supplementing individuals with HIV infection for 13 weeks with liposomal GSH (lGSH) resulted in a significant increase in the levels of TH1 cytokines, IL-1β, IL-12, IFN-γ, and TNF-α. lGSH supplementation in individuals with HIV infection also resulted in a substantial decrease in the levels of free radicals and immunosuppressive cytokines, IL-10 and TGF-β, relative to those in a placebo-controlled cohort.

PMID: 26133750

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11. Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts

Valdivia A, Ly J, Gonzalez L, Hussain P, Aing T, Islamoglu H, et al. May, 2017 in the journal AIDS Research and Human Retroviruses.

In summary, supplementation with L-GSH in HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 can help restore redox homeostasis and cytokine balance, therefore aiding the immune system to control opportunistic infections.

PMID: 28398068

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12. Effects of Oral Liposomal Glutathione in Altering the Immune Responses Against Mycobacterium tuberculosis and the Mycobacterium bovis BCG Strain in Individuals With Type 2 Diabetes

To K, Cao R, Yegiazaryan A, Owens J, Nguyen T, Sasaninia K, et al. 2021 in Frontiers in Cellular Infection Microbiology

We report that L-GSH supplementation for 3 months in people with T2DM was able to reduce the levels of oxidative stress in all blood components and prevent depletion of glutathione (GSH) in this population known to be GSH deficient.

PMID: 34150674

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13. Liposomal Glutathione Helps to Mitigate Mycobacterium tuberculosis Infection in the Lungs

Kachour N, Beever A, Owens J, Cao R, Kolloli A, Kumar R, et al. 2022 in the journal Antioxidants

Our results show that the supplementation of mice with L-GSH led to increased levels of total GSH, which is associated with reduced oxidative stress, increased levels of granuloma-promoting cytokines, and decreased M. tb burden in the lung.

PMID: 35453358

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14. L-GSH Supplementation in Conjunction With Rifampicin Augments the Treatment Response to Mycobacterium tuberculosis in a Diabetic Mouse Model

Beever A, Kachour N, Owens J, Sasaninia K, Kolloli A, Kumar R, et al. 2022 in Frontiers in Pharmacology

These findings suggest potential therapeutic benefits of L-GSH supplementation in conjunction with first-line antibiotic therapy against M. tb infection in individuals with T2DM.

PMID: 35814213